What Is An Example Of Pathological Hypertrophy? The more severe secondary hypertrophy, such as in patients who have aortic valve disease undergoing valve replacement, is not a physiological adaptation, but rather a pathological process. Recent clinical observations and experimental studies, on the other hand, have shown that reverse remodeling occurs and pathological cardiac hypertrophy can be reversed.īecause an echocardiogram shows thickening of the heart walls, it is the most commonly used test for diagnosing hypertrophic cardiomyopathy. Societies may provide access to their members by establishing personal accounts with Oxford Academic.Ī common cause of pathological cardiac hypertrophy is high blood pressure (hypertension), and heart valve abnormalities are thought to be a major independent risk factor for morbidity and mortality. A personal account will be required to sign in. If you have an active account at an institution, you may be able to access content in one of the following ways. Institutional subscriptions are commonly used to gain access to Oxford Academic content. Pathological hypertrophy can be mild, moderate, or severe, and can sometimes be life-threatening. Pathological hypertrophy is usually characterized by an increase in size of affected tissue, but can also lead to changes in function and structure. Physiological hypertrophy is a normal and healthy response to exercise, while pathological hypertrophy is an abnormal growth response that can occur in response to various diseases or conditions. There are two types of hypertrophy: physiological and pathological.
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